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Postdoctoral position at the Gene Function Lab

Postdoctoral position at the Gene Function Lab

The Institute

The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by high-end and innovative technologies.

In April 2021, the Centre for Genomic Regulation (CRG) received the renewal of the 'HR Excellence in Research' Award from the European Commission. This is a recognition of the Institute's commitment to developing an HR Strategy for Researchers, designed to bring the practices and procedures in line with the principles of the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers (Charter and Code).

Please, check out our Recruitment Policy

The role

A postdoctoral research position is available in Dr. de la Luna’s laboratory to carry out a research project on DYRK kinases as regulators of transcription. We have shown that one of the DYRK family members, DYRK1A, is recruited to promoter regions of a subset of genes where it acts as a CTD-kinase (Mol Cell, 57: 506-520, 2015, doi:10.1016/j.molcel.2014.12.026). The project aims to explore whether other members of the DYRK family are able to perform this role and if so, identify commonalities/differences with DYRK1A’s activity.

About the lab

The lab works on a family of protein kinases known as DYRK (dual-specificity tyrosine-regulated kinases), whose members -DYRK1A, DYRK1B, DYRK2, DYRK3, DYRK4- participate in the regulation of processes critical for cell viability and homeostasis. In general, alterations in DYRKs (expression or mutation) are linked to different cancer types. In addition, mutations in several DYRK genes are associated to developmental disorders, as in the case of the DYRK1A haploinsufficiency syndrome or the DYRK1B-associated metabolic syndrome. The group aims to dissect how DYRK activities are linked to human pathology. We are particularly interested on the DYRK-associated activities that impact on the regulation of expression programs either directly on chromatin or indirectly through modulation of signaling pathways. Publications of the group include Gut, 68:1465-1476, 2019. [doi:10.1136/gutjnl-2018-316128]; Cell Rep, 23:1867-1878, 2018. [doi:10.1016/j.celrep.2018.04.008]; Mol Cell, 57: 506-520, 2015. [doi:10.1016/j.molcel.2014.12.026]

Whom would we like to hire?

Professional experience

Must Have

• You have proven experience in molecular biology techniques

• You have an interest and a good understanding of transcriptional regulatory processes occurring at the chromatin level

• You have proven experience in performing and interpreting ChIP-Seq and RNA-Seq experiments

Desirable but not required/ Nice to have

• You have a first author publication record in international peer-reviewed journals

Education and training

• You hold a PhD degree in Molecular Biology, Biochemistry, Biotechnology or similar

• PhD Thesis defended from 2018 onwards

Languages

• You are fluent in English

Competences

• You have highly developed organization skills

• You have dedication, motivation, and rigor in scientific pursuits

• You have both the ability to work within a team and independent working skills

The Offer – Working Conditions

• Contract duration: 2-years.
• Estimated annual gross salary: Salary is commensurate with qualifications and consistent with our pay scales.
• Target start date: As soon as possible.

We provide a highly stimulating environment with state-of-the-art infrastructures, and unique professional career development opportunities. To check out our training and development portfolio, please visit our website in the training section.

We offer and promote a diverse and inclusive environment and welcomes applicants regardless of age, disability, gender, nationality, ethnicity, religion, sexual orientation or gender identity.

The CRG is committed to reconcile a work and family life of its employees and are offering extended vacation period and the possibility to benefit from flexible working hours.

Application Procedure

All applications must include:

1. A motivation letter addressed to Dr Susana de la Luna.
2. A complete CV including contact details.
3. Contact details of two referees.

All applications must be addressed to Dr. Susana de la Luna and be submitted online on the "Apply" button below.

Selection Process

₋ Pre-selection: The pre-selection process will be based on qualifications and expertise reflected on the candidates CVs. It will be merit-based.

₋ Interview: Preselected candidates will be interviewed.

₋ Offer Letter: Once the successful candidate is identified the Human Resources department will send a Job Offer, specifying the start day, salary, working conditions, among other important details.

Deadline: Please submit your application by January 31st, 2022.

Suggestions: The CRG believes in ongoing improvement and promotes a culture of feedback. This is one of the reasons we have in place, at your disposal as a candidate, a mechanism to gather your suggestions/complaints concerning your candidate experience in our recruitment processes. Your feedback really matters to us in our aim at creating a positive candidate journey. You can make a difference and help us improve by letting us know your suggestions through the following form.

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