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Postdoctoral Position – Understanding amyloid nucleation and cross nucleation using deep mutational scanning

Postdoctoral Position – Understanding amyloid nucleation and cross nucleation using deep mutational scanning

The Institute

The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG shares principles of an interdisciplinary, motivated and creative scientific team that is supported by high-end and innovative technologies and a flexible and efficient administration.

In April 2021, the Centre for Genomic Regulation (CRG) received the renewal of the 'HR Excellence in Research' Award from the European Commission. This is a recognition of the Institute's commitment to developing an HR Strategy for Researchers, designed to bring the practices and procedures in line with the principles of the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers (Charter and Code).

Please, check out our Recruitment Policy

The role

We are looking for a Postdoctoral candidate to join the Genetics Systems Lab at CRG.
The candidate will use deep mutational scanning approaches to understand the process of amyloid fibril nucleation and cross-nucleation.

About the team

The Genetic Systems labs works on fundamental questions in genetics and epigenetics using different systems and approaches, including model organisms and human genetic data, choosing the system and approach for the question at hand. Recent questions we have addressed include understanding mutational processes in cancer genomes, noise, inter- and trans-generational epigenetics, genetic interactions and genetic prediction. This creates an interdisciplinary and collaborative environment with many members of the lab using both experimental and computational approaches. All lab members lead their own projects. 

The Genetic Systems lab is part of the CRG Systems Biology Programme, which is a unique centre of excellence in Europe for quantitative biology.  The CRG and the other institutes of the PRBB including EMBL Barcelona provide an ideal ecosystem for this programme, being very strong in genomics, mechanistic and quantitative biology.

Work in the lab is funded by the European Research Council (ERC), Bettencourt Schueller Foundation, the Catalan and Spanish governments, and substantial core funding from the CRG. 12 recent alumni from the lab are now principal investigators in some of the very best institutes (Cambridge, Oxford, MRC/Imperial, Leuven, FMI Basel, IMBA Vienna, ENS Lyon, IIT India, CNIO Madrid, and IRB, IBEC and IJC Barcelona).

We recently initiated a new research direction that uses systematic (‘deep’) mutagenesis to quantify, understand, and predict how diverse mutations interact non-additively within and between molecules to affect phenotypes at multiple scales. We have applied this approach to individual exons (Cell 2019) and genes (Nature 2018), protein interactions (Elife 2018), regulatory interactions (Biorxiv 2019), gene networks (Nature comms 2019), prion-like domains (Nature comms 2019b) and amyloid fibrils (elife 2021).

Whom would we like to hire?

Professional experience

Must Have

• You have an excellent publication record
• You have experience with deep mutational scanning, directed/experimental evolution, protein engineering, biophysics, synthetic biology, protein aggregation, or genomics
• You are interested in bioinformatics and statistics

Desirable but not required

• You have experience with computational biology and statistics

Education and training

• You hold a PhD in molecular biology or related discipline


• You are fluent in English


• You are passionate about understanding biology
• You are organized and hard-working with a ‘can do’ attitude and a good finisher
• You have excellent communication skills
• You enjoy bold projects and taking on challenges
• You can work in a multidisciplinary team consisting of people from diverse backgrounds

The Offer – Working Conditions

Contract duration: 1 year with possibility of extension.
Estimated annual gross salary: Salary is commensurate with qualifications and consistent with our pay scales.
Target start date: September, 2021.

We provide a highly stimulating environment with state-of-the-art infrastructures, and unique professional career development opportunities. To check out our training and development portfolio, please visit our website in the training section.

We offer and promote a diverse and inclusive environment and welcomes applicants regardless of age, disability, gender, nationality, ethnicity, religion, sexual orientation or gender identity.

The CRG is committed to reconcile a work and family life of its employees and are offering extended vacation period and the possibility to benefit from flexible working hours.

Application Procedure

All applications must include:

1. A motivation letter addressed to Dr. Ben Lehner.
2. A complete CV including contact details.
3. Contact details of two referees.

All applications must be addressed to Dr. Ben Lehner and be submitted online through the "Apply" button below. 

Selection Process

Pre-selection: The pre-selection process will be based on qualifications and expertise reflected on the candidates CVS. It will be merit-based.

Interview: Preselected candidates will be interviewed by the Hiring Manager of the position and a selection panel if required.

Offer Letter: Once the successful candidate is identified the Human Resources department will send a Job Offer, specifying the start day, salary, working conditions, among other important details.

Deadline: Please submit your application by July 28th, 2021.

Suggestions: The CRG believes in ongoing improvement and promotes a culture of feedback. This is one of the reasons we have in place, at your disposal as a candidate, a mechanism to gather your suggestions/complaints concerning your candidate experience in our recruitment processes. Your feedback really matters to us in our aim at creating a positive candidate journey. You can make a difference and help us improve by letting us know your suggestions through the following form.

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