Post Doc in the Mechanics of Organelle Remodeling and Cell and Tissue Dynamics Laboratory
The Institute
The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by high-end and innovative technologies.
In April 2021, the Centre for Genomic Regulation (CRG) received the renewal of the 'HR Excellence in Research' Award from the European Commission. This is a recognition of the Institute's commitment to developing an HR Strategy for Researchers, designed to bring the practices and procedures in line with the principles of the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers (Charter and Code).
The role
The successful candidate will address a critical question in mechanobiology: how mechanical forces relate to nuclear RNA-processing organelles (biomolecular condensates) in health and/or disease? Using interdisciplinary approaches, the candidates will explore how cytoskeletal forces impact nuclear dynamics across scales, from organelle remodeling down to RNA-processing regulation, and how this physical link influences cell division.
About the team/ lab/ department
Group leaders: Adel Al Jord, PhD & Verena Ruprecht, PhD
A prominent research focus of the Al Jord Lab is the relation between physical forces and the remodeling of essential nuclear RNA-processing organelles known as biomolecular condensates. We pioneered in revealing that, in germ cells, cytoskeletal forces mechanically remodel and regulate nuclear condensates across scales for reproductive success. Whether somatic cells, which compose the majority of cells in an organism, evolved this mechanical mechanism of organelle remodeling remains a mystery. However, our new evidence indicates that this mechanism is deployed by mammalian somatic cells within diverse physiological and pathological contexts. We therefore aim to venture into these unexplored grounds of nuclear condensate mechano-regulation across somatic cell types in health and disease. The research objective is to decipher how cytoskeletal forces impact nuclear dynamics across scales, from organelle remodeling down to RNA-processing regulation, and how this physical link influences somatic cell division and specialization. To attain this aim, our research follows a cross-disciplinary approach, bridging methods from systems, cell, molecular, and synthetic biology along with computational and biophysical tools. This comprises techniques like protein multiplexing, advanced imaging, optogenetics, and force measurement and modulation assays.
Whom would we like to hire?
Professional experience
Must Have
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The candidate must hold a PhD, preferably in Cell & Molecular Biology, Oncology, or Biophysics
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Lab experience with mammalian cell culture and common techniques in Cell & Molecular biology
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Experience with advanced imaging and image analyses
Desirable but not required/ Nice to have
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Experience with transcriptomics
Languages
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Fluency in English
Computer skills
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Advanced MS Office and Prism experience
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Skilled with image and data analyses software
Competences
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Rigor, organization, and autonomy
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Strong analytical, interpersonal, and communication skills
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Curiosity and critical thinking
The Offer – Working Conditions
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Contract duration: Technical and scientific activities contract linked to the project - estimated 18 months with extension possibility.
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Estimated annual gross salary: Salary is commensurate with qualifications and consistent with our pay scales.
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Target start date: November 2024.
We provide a highly stimulating environment with state-of-the-art infrastructures, and unique professional career development opportunities. To check out our training and development portfolio, please visit our website in the training section.
We offer and promote a diverse and inclusive environment and welcomes applicants regardless of age, disability, gender, nationality, ethnicity, religion, sexual orientation or gender identity.
The CRG is committed to reconcile a work and family life of its employees and are offering extended vacation period and the possibility to benefit from flexible working hours.
Application Procedure
All applications must include:
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A motivation letter addressed to Dr Adel Al Jord/Dr Verena Ruprecht.
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A complete CV including contact details.
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Contact details of two referees.
All applications must be addressed to Dr. Adel Al Jord and be submitted online on the CRG Career site - http://www.crg.eu/en/content/careers/job-opportunities
Selection Process
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Pre-selection: The pre-selection process will be based on qualifications and expertise reflected on the candidates CVS. It will be merit-based.
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Interview: Preselected candidates will be interviewed by the Hiring Manager of the position and a selection panel if required.
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Offer Letter: Once the successful candidate is identified the People department will send a Job Offer, specifying the start day, salary, working conditions, among other important details.
Deadline: Please submit your application before 04/10/2024.
1. Ref.oficial: 101046620 / EIC-PATHFINDER.
2. This project has received funding from the European Union's Horizon Europe under the grant agreement No PLAST_CELL_101046620]"“Funded by the European Union.
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