PhD student Bioinformatics
The Institute
The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by high-end and innovative technologies.
In April 2021, the Centre for Genomic Regulation (CRG) received the renewal of the 'HR Excellence in Research' Award from the European Commission. This is a recognition of the Institute's commitment to developing an HR Strategy for Researchers, designed to bring the practices and procedures in line with the principles of the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers (Charter and Code).
The role
The “Single cell and Synthetic Genomics of Blood Formation” is looking for a motivated PhD student in bioinformatics. The student will work on a project related to lineage tracing in the hematopoietic system. Specifically, we have recently developed a new approach for tracking hematopoietic stem cell clones through their differentiation, using epimutations and single cell DNA methylation readouts (see biorxiv preprint). The student will further develop the application of this method to human blood- ansd bone marrow samples and in particular investigate alterations to clonal dynamics and clonal stem cell function during ageing. The student will be mainly responsible for the data analysis in this project.
About the lab
My interdisciplinary group investigates the biology of hematopoietic stem cells using a combination of single cell genomics, genetic screens, and computational biology. We strive to develop novel genomic and bioinformatic tools to answer longstanding questions in the field. In particular, we cover two main research lines, a) Gene regulation in healthy hematopoiesis) and b) Clonal composition of the hematopoietic system in health and leukemia. The lab has been established in January 2020 and currently consists of 7 members: Three PhD students, two postdocs and two technicians. We receive funding from the Spanish and German governments, the European Commission, the European Hematology Association and the Spanish Association against Cancer (AECC).
Whom would we like to hire?
Professional experience
Must Have
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You have experience with the computational analysis of single cell data
Desirable but not required/ Nice to have
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Experience with the computational analysis of DNA methylation data
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Basic experience in the wet lab
Education and training
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Candidates should have a University Degree and a master's degree in bioinformatics, molecular biology, biotechnology or a related discipling within the European Higher Education System (minimum 300 ECTS) or equivalent by October 2024
Languages
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You are proficient in English
Technical skills
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R and/or python programming
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Data visualization (e.g. ggplot2)
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Basic machine learning and statistics knowledge
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Unix command line
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github
Competences
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Strong abilities to work as part of a team
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Strong communication skills
The Offer – Working Conditions
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Contract duration: 4 year PhD student position
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Estimated annual gross salary: Salary is commensurate with qualifications and consistent with our pay scales
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Target start date: September 2024
We provide a highly stimulating environment with state-of-the-art infrastructures, and unique professional career development opportunities. To check out our training and development portfolio, please visit our website in the training section.
We offer and promote a diverse and inclusive environment and welcomes applicants regardless of age, disability, gender, nationality, ethnicity, religion, sexual orientation or gender identity.
The CRG is committed to reconcile a work and family life of its employees and are offering extended vacation period and the possibility to benefit from flexible working hours.
Application Procedure
All applications must include:
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A motivation letter addressed to Dr Lars Velten.
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A complete CV including contact details.
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Contact details of two referees.
All applications must be addressed to Dr. Lars Velten and be submitted online through the "Apply" button below.
Selection Process
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Pre-selection: The pre-selection process will be based on qualifications and expertise reflected on the candidates CVS. It will be merit-based.
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Interview: Preselected candidates will be interviewed by the Hiring Manager of the position and a selection panel if required.
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Offer Letter: Once the successful candidate is identified the People department will send a Job Offer, specifying the start day, salary, working conditions, among other important details.
Deadline: Please submit your application by 31/5/2024
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