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Ph.D position: Complex Causality in Aging

Ph.D position: Complex Causality in Aging

The Institute

The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by high-end and innovative technologies.

In April 2021, the Centre for Genomic Regulation (CRG) received the renewal of the 'HR Excellence in Research' Award from the European Commission. This is a recognition of the Institute's commitment to developing an HR Strategy for Researchers, designed to bring the practices and procedures in line with the principles of the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers (Charter and Code).

Please, check out our Recruitment Policy

The role

The molecular mechanisms driving aging are embedded in complex physiologic networks. At long time-scales, these mechanisms exhibit emergent, collective behaviour that is both a fascinating topic and a fundamental barrier for traditional experimental approaches to establish molecular-level causality.  To understand biological aging and develop effective therapies against it, we need better and more quantitative approaches that can rapidly characterize the multiple, complex causal pathways through which molecular-level changes determine systems-level dynamics. 

The Dynamics of Living Systems group is an interdisciplinary team that pursues these goals through a mix of molecular genetics, synthetic biology, high-throughput imaging, machine learning, modelling, and math.

We are currently looking for two candidate profiles:
• Students interested in wet-lab experiments, with a masters degree in genetics, genomics, biomedical engineering, or molecular biology
• Students interested in computational work, with a masters in engineering statistics, physics, computer science or bioinformatics
The group is led by Nicholas Stroustrup, Ph.D Systems Biology, B.S.E Electrical Engineering.  For more information, check out our research website: http://lifespanmachine.crg.eu.

The successful candidate will:
• Collaborate on the development of novel experimental and computational methods to study the genetics and molecular physiology of aging.
• Develop new functional genomics approaches for measuring change at the single cell, individual, and population level.
• Work with C. elegans as a fast-aging and genetically tractable model for prototyping approaches that can be transferred to vertebrate models and humans.
• Engage in close wet-lab / dry-lab collaborations to develop new experimental methods
• Join in regular journal clubs, departmental data clubs, and institutional symposia
• Work with the lab’s high-throughput imaging technology “The Lifespan Machine”.
• Interact with colleagues the CNAG (centro nacional de análisis genómico) Single Cell Genomics Team and CRG Genomics Core, as well as colleagues located in biology, physics, and engineering departments at multiple institutes and universities across Barcelona.

About the team

We are a small, international team that combines expertise in genetics, molecular biology, physics, computational biology, and engineering.  We are based in the EMBL/CRG Systems Biology Unit in Barcelona, Spain, which is an unusually great place to live and do science. We build and apply new technologies that allow us to collect the data needed to build quantitatively rigorous models of physiology.

Whom would we like to hire?

Professional experience

Must Have

• You hold a Master´s degree or similar equivalent
• You have substantial research experience in life sciences, engineering, or physics
• You are interested in working in a highly interdisciplinary environment

Desirable but not required/ Nice to have

• You have experience in microbial, inverterate, or human genetics


• You are proficient in English


• You have highly developed organizational skills
• You are proactive

The Offer – Working Conditions

• Contract duration: 4-year contract.
Estimated annual gross salary: Salary is commensurate with qualifications and consistent with our pay scales.
• Target start date: Fall 2022.

We provide a highly stimulating environment with state-of-the-art infrastructures, and unique professional career development opportunities. To check out our training and development portfolio, please visit our website in the training section.

We offer and promote a diverse and inclusive environment and welcomes applicants regardless of age, disability, gender, nationality, race, religion or sexual orientation.

The CRG is committed to reconcile a work and family life of its employees and are offering extended vacation period and the possibility to benefit from flexible working hours.

Application Procedure

All applications must include:
1. A motivation letter addressed to Dr. Nicholas Stroustrup.
2. A complete CV including contact details.
3. Contact details of two referees.

All applications must be addressed to Dr. Nicholas Stroustrup and be submitted online on the CRG "Apply" button below.

Interested candidates can also email Nicholas directly for more information: nicholas.stroustrup@crg.eu

Selection Process

₋ Pre-selection: The pre-selection process will be based on qualifications and expertise reflected on the candidates CVS. It will be merit-based.

₋ Interview: Preselected candidates will present their recent research in front of the Dynamics of Living Systems group, associated CRG laboratories and Graduate Committee.

₋ Offer Letter: Once the successful candidate is identified the Human Resources department will send a Job Offer, specifying the start day, salary, working conditions, among other important details.

Deadline: Please submit your application by October 1st, 2022, but candidates will be considered on a rolling application basis.

Suggestions: The CRG believes in ongoing improvement and promotes a culture of feedback. This is one of the reasons we have in place, at your disposal as a candidate, a mechanism to gather your suggestions/complaints concerning your candidate experience in our recruitment processes. Your feedback really matters to us in our aim at creating a positive candidate journey. You can make a difference and help us improve by letting us know your suggestions through the following form.

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