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Evolution of Chromatin Architecture - Postdoctoral Fellow

Evolution of Chromatin Architecture - Postdoctoral Fellow

The Institute

The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG shares principles of an interdisciplinary, motivated and creative scientific team that is supported by high-end and innovative technologies and a flexible and efficient administration.

In November 2013, the Centre for Genomic Regulation (CRG) received the 'HR Excellence in Research' logo from the European Commission. This is a recognition of the Institute's commitment to developing an HR Strategy for Researchers, designed to bring the practices and procedures in line with the principles of the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers (Charter and Code).

Please, check out our Recruitment Policy

The role

The successful candidate will comparatively study the regulatory genome architectures of phylogenetically diverse animal species (and closely related unicellular allies) to understand the evolution of multicellular gene regulation. The position will entail both performing chromatin profiling experiments (mostly HiC/HiChIP), as well as analysing and integrating this data to derive evolutionary insights. The work will be part of our ERC-funded project EvoCellMap, which aims at understanding how animal cell type and the associated genome regulation originates and evolves. The candidate will be part of a highly interdisciplinay, international and dynamic team composed by the Sebe-Pedros and Marti-Renom groups, which include developmental, computational, evolutionary and molecular biologists.

About the team

The Sebe-Pedros Group (https://www.crg.eu/en/programmes-groups/sebe-pedros-lab) studies genome regulation from an evolutionary systems perspective. In particular, we are interested in deciphering the evolutionary dynamics of animal cell type gene regulatory networks and in reconstructing the evolution of genome regulatory mechanisms (from transcription factor binding through chromatin states to the physical architecture of the genome). To this end, we combine phylogenetics tools with functional genomics and proteomics methods (chromatin profiling, single-cell genomics) in order to characterize and compare cell types and epigenomic landscapes in non-model animal and other eukaryotic species.

The Marti-Renom Group (http://marciuslab.org) at the National Center for Genomic Analysis - Centre for Genomic Regulation (CNAG-CRG) develops and uses experimental and computational approaches for characterizing the molecular regulation of cells by studying the structure of macromolecules and their complexes. In particular, we focus on regulatory molecules such as RNA and chromatin.

For further information you can directly email the PIs of the groups: arnau.sebe@crg.eu, martirenom@cnag.crg.eu

Whom would we like to hire? 

Professional experience

Must Have

  • You have hands-on experience in basic molecular biology.
  • You have experience in Python and/or R.

Desirable but not required

  • You have experience in computational biology, in particular epigenomic data analysis.
  • You have experience in chromatin experimental methods (e.g. ChIP-seq, ATAC), in particular.3C/Hi-C methods.
  • You have hands-on experience in basic genomics workflows (e.g. library preparation).

Education and training

  • You hold a PhD in Biology, Bioinformatics or similar.

Languages

  • You are fluent in English.

Competences

  • You have highly developed organization and coordination skills.
  • You have dedication, motivation, and rigor in scientific pursuits.
  • You have capacity to work both independently and as part of a team.

The Offer – Working Conditions

  • Contract duration: 2 years (with possibility to extend it with external fellowships)
  • Estimated annual gross salary: Salary is commensurate with qualifications and consistent with our pay scales.
  • Target start date: February 2020

We provide a highly stimulating environment with state-of-the-art infrastructures, and unique professional career development opportunities. To check out our training and development portfolio, please visit our website in the training section.

We offer and promote a diverse and inclusive environment and welcomes applicants regardless of age, disability, gender, nationality, race, religion or sexual orientation.

The CRG is committed to reconcile a work and family life of its employees and are offering extended vacation period and the possibility to benefit from flexible working hours.

Application Procedure

All applications must include:

  1. A motivation letter addressed to Dr A. Sebé-Pedrós/Dr. Marc A. Marti-Renom.
  2. A complete CV including contact details.
  3. Contact details of two referees.

All applications must be submitted online through the "Apply" button below.

Selection Process

  • Pre-selection: The pre-selection process will be based on qualifications and expertise reflected on the candidates CVS. It will be merit-based.
  • Interview: Preselected candidates will be contacted to coordinate an interview with the PI.
  • Offer Letter: Once the successful candidate is identified the Human Resources department will send a Job Offer, specifying the start day, salary, working conditions, among other important details.

Deadline: Please submit your application by January 31st 2020.

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