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Bioinformatician - Single Cell Epigenomics and Cancer Development lab

Bioinformatician - Single Cell Epigenomics and Cancer Development lab

The Institute

The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by high-end and innovative technologies.

In April 2021, the Centre for Genomic Regulation (CRG) received the renewal of the 'HR Excellence in Research' Award from the European Commission. This is a recognition of the Institute's commitment to developing an HR Strategy for Researchers, designed to bring the practices and procedures in line with the principles of the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers (Charter and Code).

Please, check out our Recruitment Policy

The role

We are looking for an enthusiastic and motivated bioinformatician to join the Single Cell Epigenomics and Cancer Development team to provide support in creating a better understanding of early tumor formation. The candidate will lead the data analysis of different single-cell technology and 3D chromatin organisation-based projects and will provide bioinformatic support to other team members in the lab, both at the level of experimental design and data analysis. The selected candidate will also be responsible for keeping our system to store sequencing data up to date.

The layers that we aim to address in the lab at the single-cell level comprise gene expression, chromatin accessibility, DNA methylation and somatic mutations. At the level of 3D chromatin organisation, we will focus on HiC and Capture HiC data and variant calling to study allele specific effects.

About the lab

Tumors originate from normal cells that acquire tumor-initiating genetic events, such as translocations and somatic mutations. These genetic hits turn normal cells into pre-malignant cells, but do not lead to immediate tumor formation. For that, secondary genetic events as well as epigenetic hits are required.

We aim to create a better understanding of how epigenetic tumor-associated changes arise in the context of non-Hodgkin lymphomas. To that end, we aim to study the occurrence of these changes in healthy individuals as well as in pre-malignant cells in vitro (to be created by CRISPR/Cas9 genomic editing) and in vivo using single-cell technologies. On top of that, we aim to define cell intrinsic mechanisms, such as enhancer activation and 3D chromatin interactions, that influence the occurrence of the observed changes.

We are affiliated to the Gene Regulation, Stem Cell and Cancer Research program of the CRG in double affiliation with the Centre for Genomic Analysis (CNAG-CRG) and the department of Oncology and Haematology of the IDIBAPS. We strongly believe that bringing the knowledge and resources of these different environments together majorly aids to better understand the biology of disease. Further information can be found at: https://www.crg.eu/en/programmes-groups/beekman-lab.

Whom would we like to hire?

Professional experience

Must Have

• You have good knowledge of Computational Biology
• You have a background in analysis of single-cell (RNA-seq or ATAC-seq) data or epigenetic data (e.g. ChIP-seq, ATAC-seq, DNA methylation data, chromatin conformation capture data)

Desirable but not required/ Nice to have

• You have experience in data analysis of genome-wide genetic datasets and RNA-seq

Education and training

We are looking for a bioinformatician with one of the following levels of education/training:

• A master’s degree in Bioinformatics or a related discipline
• A master’s degree in the life sciences field and at least 3 years of experience in performing bioinformatic analysis
• A master’s degree in the computer science field and at least 3 years of experience in performing bioinformatic analysis

Languages

• You are fluent in English

Technical skills

• You have hands-on experience in:

o NGS data-analysis.
o Single-cell technology-based data analysis.
o Genome-wide epigenetic data analysis

• You have advanced Unix operating systems skills
• You are competent in Python, Perl or R

Competences

• You have highly developed organization skills
• You have excellent analytical and problem-solving skills
• You have enthusiasm, motivation and dedication to explore new scientific avenues
• You have the capability to work on different projects simultaneously as part of a team and/or independently

The Offer – Working Conditions

Contract duration: 1 year with possibility of extension.
Estimated annual gross salary: Salary is commensurate with qualifications and consistent with our pay scales.
Target start date: December 2021.

We provide a highly stimulating environment with state-of-the-art infrastructures, and unique professional career development opportunities. To check out our training and development portfolio, please visit our website in the training section.

We offer and promote a diverse and inclusive environment and welcomes applicants regardless of age, disability, gender, nationality, ethnicity, religion, sexual orientation or gender identity.

The CRG is committed to reconcile a work and family life of its employees and are offering extended vacation period and the possibility to benefit from flexible working hours.

Application Procedure

All applications must include:

1. A motivation letter addressed to Dr. Renée Beekman.
2. A complete CV including contact details.
3. Contact details of two referees.

All applications must be addressed to Dr. Renée Beekman and be submitted through the "Apply" button below. 

Selection Process

Pre-selection: The pre-selection process will be based on qualifications and expertise reflected on the candidates CVS. It will be merit-based.

Interview: Preselected candidates will be contacted to coordinate an interview with the PI.

Offer Letter: Once the successful candidate is identified the Human Resources department will send a Job Offer, specifying the start day, salary, working conditions, among other important details.

Deadline: Please submit your application by November 8th, 2021.

Suggestions: The CRG believes in ongoing improvement and promotes a culture of feedback. This is one of the reasons we have in place, at your disposal as a candidate, a mechanism to gather your suggestions/complaints concerning your candidate experience in our recruitment processes. Your feedback really matters to us in our aim at creating a positive candidate journey. You can make a difference and help us improve by letting us know your suggestions through the following form.

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